Humanin: A Cytoprotective Mitochondrial Peptide
Abstract Humanin, a 24-amino acid mitochondrial-derived peptide, was discovered in 2001 during Alzheimer’s disease (AD) research. Its unique genetic origin […]
Mitochondria
Who Might Benefit from ERR‑Agonist Exercise Mimetics like SLU-PP-332?
Part 1: Exercise Mimetics 101: Why ERRs Matter for Metabolic Health Part 2: SLU‑PP‑332: An ERR that Reprograms Muscle Fuel
SLU‑PP‑332: Safety, Caveats, and Comparators
Part 1: Exercise Mimetics 101: Why ERRs Matter for Metabolic Health Part 2: SLU‑PP‑332: An ERR that Reprograms Muscle Fuel
SLU‑PP‑332: An ERR that Reprograms Muscle Fuel Use
By activating ERRs, SLU‑PP‑332 binds to ERRs that turn on a PGC‑1α–linked endurance program. This program creates more mitochondria, shifts to fat as primary fuel, and increases exercise capacity in mice.
Exercise Mimetics 101: Why ERRs Matter for Metabolic Health
Abstract: SLU-PP-332 the exercise mimetic. Exercise mimetics are compounds designed to copy the molecular effects of exercise. One of